The pathophysiology of septic shock is his primary laboratory interest, including the early events that occur in the host-pathogen interaction following bacterial infection. Clinical trial design and analysis from phase I to phase III trials in critical care is his primary clinical research focus. He has published over 350 peer-reviewed, research papers, invited reviews and editorials, and has authored nearly 100 book chapters in infectious disease and critical care medicine. He is an editorial board member of a number of academic research journals and is the senior editor of a major text book of infectious diseases. He is a fellow of the Infectious Disease Society of America. His research has been funded by grants from biotechnology companies, the NIH and the European Union.