Dr. Christie’s career is Section Chief of Medical Critical Care and Director of the Center for Translational Lung Biology at Penn. His career is focused on translational research studies of the risks, pathogenesis, classification, treatment, and outcomes of lung injury in the transplant and non-transplant human populations. Dr. Christie led efforts to define the syndrome of primary graft dysfunction (PGD) following lung transplantation, and has elucidated the clinical and molecular epidemiology of this syndrome. In closely related research in trauma and sepsis populations, Dr. Christie has refined the ARDS definition for use in translational research studies, has applied large scale genotyping methods to identify variation in the ANGTP2 and IL1RN genes as significant ARDS risks and led the effort on the first genome-wide association study of ARDS in trauma subjects, prioritizing liprin-alpha for future ARDS mechanistic studies.